Search results for "Small vessel vasculiti"

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Difference in the expression of IL-9 and IL-17 correlates with different histological pattern of vascular wall injury in giant cell arteritis

2015

OBJECTIVE: GCA is a large- and medium-vessel arteritis characterized by a range of histological patterns of vascular wall injury. The aim of this study was to immunologically characterize the various histological patterns of GCA. METHODS: Thirty-five consecutive patients with biopsy-proven GCA and 15 normal controls were studied. IL-8, IL-9, IL-9R, IL-17, IL-4, TGF-β and thymic stromal lymphopoietin expression was evaluated by RT-PCR and immunohistochemistry on artery biopsy specimens. Confocal microscopy was used to characterize the phenotypes of IL-9-producing and IL-9R-expressing cells. Five additional patients who had received prednisone when the temporal artery biopsy was performed wer…

MalePathologyBiopsyT-LymphocytesSettore BIO/13 - Biologia ApplicataTransforming Growth Factor betaTh9Pharmacology (medical)Aged 80 and overMicroscopy Confocalmedicine.diagnostic_testSmall vessel vasculitisVasa vasorum vasculitiInterleukin-17vasa vasorum vasculitis Giant cell arteritiMiddle AgedTemporal Arteriesmedicine.anatomical_structurePhenotypeVasa vasorum vasculitisSmall vessel vasculitiCytokinesFemaleTh17medicine.symptomVasculitisgiant cell arteritimedicine.medical_specialtyThymic stromal lymphopoietinGiant Cell ArteritisInflammationThymic Stromal LymphopoietinRheumatologyBiopsyTh17; Th9; giant cell arteritis; small vessel vasculitis; vasa vasorum vasculitismedicineHumansInterleukin 9ArteritisGlucocorticoidsAgedbusiness.industryInterleukin-9Vascular System Injuriesmedicine.diseaseGiant cell arteritisSettore MED/16 - ReumatologiaVasa vasorumCase-Control StudiesImmunologyPrednisonebusinessBiomarkers
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Kawasaki disease in Sicily: clinical description and markers of disease severity

2016

Background: Kawasaki disease (KD) is an acute systemic vasculitis of small and middle size arteries; 15-25 % of untreated patients and 5 % of patients treated with intravenous immunoglobulin (IVIG) develop coronary artery lesions (CAL). Many studies tried to find the most effective treatment in the management of resistant KD and to select the risk factors for CAL. Our data are assessed on children from west Sicily, characterized by a genetic heterogeneity. Methods: We studied the clinical data of 70 KD Sicilian children (36 males: 51 %; 34 females: 49 %), analysed retrospectively, including: demographic and laboratory parameters; echocardiographic findings at diagnosis, at 2, 6 and 8 weeks,…

VasculitisMaleVasculitimedicine.medical_specialtyCardiovascular Disease; Kawasaki Disease; Small Vessel Vasculitis; Vasculitis030204 cardiovascular system & hematologyMucocutaneous Lymph Node SyndromeSeverity of Illness IndexSmall Vessel Vasculitis03 medical and health sciencesSettore MED/38 - Pediatria Generale E Specialistica0302 clinical medicineDisease severity030225 pediatricshemic and lymphatic diseasesCardiovascular DiseaseMedicineEffective treatmentHumansKawasaki DiseaseSicilyCardiovascular Disease; Kawasaki Disease; Small Vessel Vasculitis; Vasculitis; Pediatrics Perinatology and Child HealthRetrospective Studiesbiologybusiness.industryGenetic heterogeneityResearchmedicine.diseaseDermatologySmall Vessel Vasculitimedicine.anatomical_structureEchocardiographyChild PreschoolPediatrics Perinatology and Child HealthImmunologybiology.proteinKawasaki diseaseFemaleAntibodybusinessVasculitisBiomarkersSystemic vasculitisArteryItalian Journal of Pediatrics
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